One basic piece of advice is to closely observe the cards your opponents discard; this can give you important information about their hand and guide your own choices. An ophello rummyponent may not be pursuing that specific set or run, for example, if they discard a card that you need for a meld. Effective hand management requires striking a balance between forming melds and leaving your options open. As the game progresses, it can be beneficial to hold onto versatile cards that can contribute to several possible melds.