Extended periods of stress can be harmful to one's physical & mental well-being, resulting in conditions like anxiety, depression, hypertension, and immune system weakness. Mindfulness Medirummy rs51tation as an Antidote to Stress. Through the cultivation of a sense of calm and relaxation in the face of life's challenges, mindfulness meditation provides a potent antidote to stress. Studies have indicated that practicing mindfulness meditation on a regular basis can improve general well-being, decrease anxiety symptoms, and decrease levels of the stress hormone cortisol.